(Nitromethyl)benzene → 6-Nitro-6-phenylhex-5-enal

HRID 1193016

반응식

HRID 1193016 반응식
[N+:1]([CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)([O-:3])=[O:2].C[O:12][CH:13](OC)[CH2:14][CH2:15][CH2:16][CH:17]=O>CCOC(C)=O.CCCCCC>[N+:1]([C:4]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[CH:17][CH2:16][CH2:15][CH2:14][CH:13]=[O:12])([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 69321(Nitromethyl)benzeneHCID 170903Pentanal, 5,5-dimethoxy-

생성물 1

HCID 765529406-Nitro-6-phenylhex-5-enal수율 41.1%

시약·촉매·용매 1

HCID 21226206Ethyl acetate hexane용매

실험 절차

Prepared according to the general procedure B from 1-(nitromethyl)benzene 112d (24 mmol) and 5,5-dimethoxypentanal 131 (16 mmol) to provide the title compound as yellow oil (E/Z=6.7/1) (1.44 g, 41% yield) after silica gel chromatography (EtOAc/Hexane).

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-088268a327994039bea3fca27f7f92b0
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08680335B2

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