2-Chloro-4-(trifluoromethyl)pyrimidine → (1R,6S)-8-(5-Methylpyrazin-2-yl)-3,8-diazabicyclo[4.2.0]octane

반응식

FC(F)(F)[C:3]1[CH:8]=[CH:7][N:6]=[C:5]([N:9]2[C@@H:16]3[C@@H:11]([CH2:12][CH2:13][NH:14][CH2:15]3)[CH2:10]2)N=1.Cl[C:20]1N=C(C(F)(F)F)C=C[N:21]=1>>[CH3:3][C:8]1[N:21]=[CH:20][C:5]([N:9]2[C@@H:16]3[C@@H:11]([CH2:12][CH2:13][NH:14][CH2:15]3)[CH2:10]2)=[N:6][CH:7]=1

참가 물질

반응물 2

HCID 27739122-Chloro-4-(trifluoromethyl)pyrimidine

HCID 67116508HCID 67116508, 화합물

생성물 1

HCID 67116692(1R,6S)-8-(5-Methylpyrazin-2-yl)-3,8-diazabicyclo[4.2.0]octane

실험 절차

The title compound was prepared in a manner analogous to Intermediate 27, substituting 2-bromo-5-methylpyrazine for 2-chloro-4-(trifluoromethyl)pyrimidine.

출처 및 근거

ORD 기록: ord-ce72c4a54d3849939146f4165242903e
출처 데이터셋: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08680275B2

반응 노트

불러오는 중…