2-Chloro-4,5,6-trimethylpyrimidine → 2-Chloro-5-ethyl-4,6-dimethylpyrimidine

반응식

[Cl:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH3:9])=[C:4]([CH3:10])[N:3]=1.[CH3:11]C1C(C)=C(C)N=C(O)N=1>>[Cl:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9][CH3:11])=[C:4]([CH3:10])[N:3]=1

참가 물질

반응물 2

HCID 125019872-Chloro-4,5,6-trimethylpyrimidine

HCID 178433497HCID 178433497, 화합물

생성물 1

HCID 198466592-Chloro-5-ethyl-4,6-dimethylpyrimidine

실험 절차

The title compound was prepared in a manner analogous to Intermediate 66, substituting 5-ethyl-4,6-dimethylpyrimidin-2-ol for 4,5,6-trimethylpyrimidin-2-ol. MS (ESI): mass calculated for C8H11ClN2, 170.06, m/z found 171.1 [M+1]+. 1H NMR (500 MHz, CDCl3): 2.65 (q, J=7.6 Hz, 2H), 2.50 (s, 6H), 1.15 (t, J=7.6 Hz, 3H).

출처 및 근거

ORD 기록: ord-36d9f2b190db49f69e24d437c64275f8
출처 데이터셋: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08680275B2

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