Acetyl chloride → N-Methyl-1-(2-methylpyridin-4-yl)azetidin-3-amine dihydrochloride

HRID 1193351노트

반응식

HRID 1193351 반응식
[CH3:1][N:2]([CH:10]1[CH2:13][N:12]([C:14]2[CH:19]=[CH:18][N:17]=[C:16]([CH3:20])[CH:15]=2)[CH2:11]1)C(=O)OC(C)(C)C.C([Cl:24])(=O)C>C(O)C>[ClH:24].[ClH:24].[CH3:1][NH:2][CH:10]1[CH2:11][N:12]([C:14]2[CH:19]=[CH:18][N:17]=[C:16]([CH3:20])[CH:15]=2)[CH2:13]1

참가 물질

4

반응물 2

HCID 6367Acetyl chlorideHCID 66805338HCID 66805338, 화합물

생성물 1

HCID 66798562N-Methyl-1-(2-methylpyridin-4-yl)azetidin-3-amine dihydrochloride수율 99%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
40 °C

실험 절차

tert-Butyl methyl(1-(2-methylpyridin-4-yl)azetidin-3-yl)carbamate (1.37 mmol, 1 eq) was dissolved in ethanol (5 ml), and acetyl chloride (6.85 mmol, 5.0 eq) was added while cooling with ice. The reaction mixture was then stirred for 2 hours at 40° C. The solvent was removed in vacuo and the residue was dried. Yield: 99%

후처리

  1. temperaturewhile cooling with ice
  2. customThe solvent was removed in vacuo
  3. customthe residue was dried

출처 및 근거

ORD 기록
ord-38812cd7c0cf4d02b14a50fd280af129
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08680159B2

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