Trifluoroacetic acid → Benzyl methyl(piperidin-4-yl)carbamate

HRID 1193373노트

반응식

HRID 1193373 반응식
[CH2:1]([O:8][C:9]([N:11]([CH3:25])[CH:12]1[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:25][N:11]([CH:12]1[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]1)[C:9](=[O:10])[O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 57753905HCID 57753905, 화합물

생성물 1

HCID 18677746Benzyl methyl(piperidin-4-yl)carbamate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

tert-Butyl 4-((benzyloxycarbonyl)(methyl)amino)piperidine-1-carboxylate (0.3 g, 0.682 mmol, 1.0 eq.) was dissolved in DCM (10 ml); TFA (2.5 ml) was added at 0° C. and stirring was carried out for 2 hours at RT. The reaction mixture was concentrated under reduced pressure, taken up several times in toluene and dried. The crude product was used in the next stage without being purified further.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customdried
  3. customwithout being purified further

출처 및 근거

ORD 기록
ord-8e1110e4de924ff7a4f9d7cb88be3303
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08680159B2

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