HCID 66798915, 화합물 → N,N-Dimethyl-4-(4-(methylamino)piperidin-1-yl)pyridin-2-amine

HRID 1193375노트

반응식

HRID 1193375 반응식
[CH3:1][N:2]([CH3:27])[C:3]1[CH:8]=[C:7]([N:9]2[CH2:14][CH2:13][CH:12]([N:15](C)[C:16](=O)OCC3C=CC=CC=3)[CH2:11][CH2:10]2)[CH:6]=[CH:5][N:4]=1>CO>[CH3:1][N:2]([CH3:27])[C:3]1[CH:8]=[C:7]([N:9]2[CH2:10][CH2:11][CH:12]([NH:15][CH3:16])[CH2:13][CH2:14]2)[CH:6]=[CH:5][N:4]=1

참가 물질

3

반응물 1

HCID 66798915HCID 66798915, 화합물

생성물 1

HCID 66798588N,N-Dimethyl-4-(4-(methylamino)piperidin-1-yl)pyridin-2-amine수율 96%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Benzyl 1-(2-(dimethylamino)pyridin-4-yl)piperidin-4-yl(methyl)carbamate (280 mg, 0.76 mmol, 1.0 eq.) was dissolved in MeOH (10 ml) and degassed with N2. Pd(OH)2 (140 mg, 50%) was then added and hydrogenation was carried out for 3 hours. After monitoring by TLC, the reaction mixture was filtered over Celite, the filtrate was concentrated under reduced pressure and the crude product was used in the next stage without being purified further. Yield: 96% (170 mg, 0.726 mmol)

후처리

  1. customdegassed with N2
  2. additionPd(OH)2 (140 mg, 50%) was then added
  3. filtrationthe reaction mixture was filtered over Celite
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. customwithout being purified further

출처 및 근거

ORD 기록
ord-33c461506ca741068a3f983b182245b4
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08680159B2

반응 노트

불러오는 중…