tert-Butyl (1-benzylpiperidin-4-yl)methylcarbamate → 4-N-Boc-4-N-Methyl-aminopiperidine

HRID 1193389노트

반응식

HRID 1193389 반응식
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:22])[C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH2:10][CH2:9]1)C1C=CC=CC=1>CO>[CH3:22][N:14]([CH:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)[C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:18])[CH3:19]

참가 물질

3

반응물 1

HCID 18476608tert-Butyl (1-benzylpiperidin-4-yl)methylcarbamate

생성물 1

HCID 27568064-N-Boc-4-N-Methyl-aminopiperidine수율 85%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

tert-Butyl 1-benzylpiperidin-4-yl(methyl)carbamate (1.0 g, 3.289 mmol, 1.0 eq.) was dissolved in MeOH (15 ml) and degassed with argon. Pd/C (300 mg) was then added and hydrogenation was carried out for 4 hours. After monitoring by TLC, the reaction mixture was filtered over Celite and the filtrate was concentrated under reduced pressure. The crude product was used in the next stage without being purified further. Yield: 85% (600 mg, 2.803 mmol)

후처리

  1. customdegassed with argon
  2. additionPd/C (300 mg) was then added
  3. filtrationthe reaction mixture was filtered over Celite
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. customwithout being purified further

출처 및 근거

ORD 기록
ord-7367616cf3984297a5c4518a2954ef88
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08680159B2

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