Methyl isothiocyanate → HCID 86663381, 화합물

HRID 1193392노트

반응식

HRID 1193392 반응식
[CH3:1][N:2]=[C:3]=[S:4].[CH3:5][N:6]([CH:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1)[C:7](=[O:16])[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>ClCCl>[CH3:5][N:6]([CH:17]1[CH2:18][CH2:19][N:20]([C:3](=[S:4])[NH:2][CH3:1])[CH2:21][CH2:22]1)[C:7](=[O:16])[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

4

반응물 2

HCID 11167Methyl isothiocyanateHCID 18677746Benzyl methyl(piperidin-4-yl)carbamate

생성물 1

HCID 86663381HCID 86663381, 화합물수율 45%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of methyl isothiocyanate (500 mg, 6.8493 mmol, 1 eq) in dichloromethane (4 ml) was added dropwise over a period of 5 min to a solution of benzyl methyl(piperidin-4-yl)carbamate (stage 3 AMN-52) (1.7 g, 6.8493 mmol, 1 eq). When the addition was complete, the reaction mixture was stirred for 20 hours at room temperature. Concentration under reduced pressure was then carried out and the crude product was purified by column chromatography (silica gel, 2% methanol in dichloromethane). Yield: 45% (1 g, 3.115 mmol)

후처리

  1. additionWhen the addition
  2. concentrationConcentration under reduced pressure
  3. customthe crude product was purified by column chromatography (silica gel, 2% methanol in dichloromethane)

출처 및 근거

ORD 기록
ord-6ac9c05858274756aebffa91cb4db4c4
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08680159B2

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