Trifluoroacetic acid → N-methyl-1-(1-methyl-1H-imidazol-2-yl)piperidin-4-amine

HRID 1193394노트

반응식

HRID 1193394 반응식
FC(F)(F)C(O)=O.[CH3:8][N:9]([CH:17]1[CH2:22][CH2:21][N:20]([C:23]2[N:24]([CH3:28])[CH:25]=[CH:26][N:27]=2)[CH2:19][CH2:18]1)C(=O)OC(C)(C)C>ClCCl>[CH3:8][NH:9][CH:17]1[CH2:22][CH2:21][N:20]([C:23]2[N:24]([CH3:28])[CH:25]=[CH:26][N:27]=2)[CH2:19][CH2:18]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 66798554tert-Butyl methyl(1-(1-methyl-1H-imidazol-2-yl)piperidin-4-yl)carbamate

생성물 1

HCID 62131647N-methyl-1-(1-methyl-1H-imidazol-2-yl)piperidin-4-amine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Trifluoroacetic acid (1 ml) was added at 0° C. to a solution of tert-butyl methyl(1-(1-methyl-1H-imidazol-2-yl)piperidin-4-yl)carbamate (241 mg, 0.82 mmol, 1 eq) in dichloromethane (5 ml), and the reaction mixture was stirred for 1 h at room temperature. Concentration under reduced pressure was then carried out. The crude product so obtained was used in the next stage without being purified further.

후처리

  1. concentrationConcentration under reduced pressure

출처 및 근거

ORD 기록
ord-291a5f2cf6774ef689cf7e3b58fdc86f
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08680159B2

반응 노트

불러오는 중…