Trifluoroacetic acid → Benzyl ethyl(piperidin-4-yl)carbamate trifluoroacetate

HRID 1193414노트

반응식

HRID 1193414 반응식
[C:1]([OH:7])([C:3]([F:6])([F:5])[F:4])=[O:2].[CH2:8]([O:15][C:16]([N:18]([CH2:32][CH3:33])[CH:19]1[CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21][CH2:20]1)=[O:17])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>C(Cl)Cl>[F:4][C:3]([F:6])([F:5])[C:1]([OH:7])=[O:2].[CH2:32]([N:18]([CH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)[C:16](=[O:17])[O:15][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH3:33]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 18677722Tert-butyl 4-(((benzyloxy)carbonyl)(ethyl)amino)piperidine-1-carboxylate

생성물 1

HCID 66799319Benzyl ethyl(piperidin-4-yl)carbamate trifluoroacetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

TFA (2.5 ml) was added at 0° C. to a solution of tert-butyl 4-((benzyloxycarbonyl)(ethyl)-amino)piperidine-1-carboxylate (1.5 g, 414 mmol, 1.0 eq) in DCM (10 ml) and the mixture was stirred for 2 hours at RT. After monitoring by TLC, the reaction mixture was concentrated under reduced pressure and dried. The crude product was used in the next stage without being purified further.

후처리

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. customdried
  3. customwithout being purified further

출처 및 근거

ORD 기록
ord-64797714bca04b9494c3d5d12c02f32f
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08680159B2

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