Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Bromo-3-chloropropane → N-[3-(3-Chloropropoxy)phenyl]urea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Bromo-3-chloropropane | HCID 8006 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | m-Hydroxyphenylurea | HCID 12796 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | N-[3-(3-Chloropropoxy)phenyl]urea | HCID 14407185 | 83.1% |
반응 단계
A mixture of 45.6 g (0.3 mole) of 1-(3-hydroxyphenyl)urea, 94.5 g (0.6 mole) of 1-bromo-3-chloropropane, 124.4 g (0.9 mole) of anhydrous potassium carbonate and 1 liter of acetone was heated at reflux with mechanical stirring for 20 hr. The mixture was concentrated and the residue was slurried with 1.5 liters of water. The mixture was filtered and the filter cake was recrystallized from isopropanol to yield 57.0 g (83%) of off-white solid, m.p. 141°-143° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04810713 |
| 출처 데이터셋 | uspto-grants-1989_03 |
| ORD ID | ord-58d5f522eb864f38ac8325b0bf7b2394 |
| 출처 메모 | uspto-grants-1989_03 |