Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 3-Hydroxymethylchrysene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Lithium borohydride | HCID 4148881 | — |
| 반응물 | Ethyl chrysene-3-carboxylate | HCID 15599328 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-Hydroxymethylchrysene | HCID 15599327 | 98.3% |
반응 단계
A solution of ethyl chrysene-3-carboxylate (19E 17.7 g, 0.059 mol) in 40 mL THF was treated with LiBH4 (Morton Thiokol, Inc.-Alfa Products, PO Box 299, 152 Andover St., Danvers, MA 01923, 2.7 g, 0.12 mol) in three portions then refluxed for 3 days. The reaction mixture was poured into ice and acidified carefully to pH 1 with 1N HCl. The precipitate was filtered and recrystallized from THF/hexane to afford 14.98 g (98%) of 3-chrysenemethanol mp 187°-189°, (C, H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04810727 |
| 출처 데이터셋 | uspto-grants-1989_03 |
| ORD ID | ord-1d648ac149284adfa7963c728af2b900 |
| 출처 메모 | uspto-grants-1989_03 |