Sulfuric Acid → 2-ethoxy-1-(4-bromo-2-fluoro-5-hydroxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone

HRID 1193933노트

반응식

[CH2:1]([O:3][C:4]1[N:5]([C:15]2[CH:20]=[C:19]([O:21]C(C)C)[C:18]([Br:25])=[CH:17][C:16]=2[F:26])[C:6](=[O:14])[CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[N:9]=1)[CH3:2].S(=O)(=O)(O)O>>[CH2:1]([O:3][C:4]1[N:5]([C:15]2[CH:20]=[C:19]([OH:21])[C:18]([Br:25])=[CH:17][C:16]=2[F:26])[C:6](=[O:14])[CH:7]=[C:8]([C:10]([F:13])([F:11])[F:12])[N:9]=1)[CH3:2]

참가 물질

반응물 2

HCID 1118Sulfuric Acid

HCID 21270761HCID 21270761, 화합물

생성물 1

HCID 212707472-ethoxy-1-(4-bromo-2-fluoro-5-hydroxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone

실험 절차

using 2-ethoxy-1-(4-bromo-2-fluoro-5-isopropoxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone with concentrated sulphuric acid during 2 minutes at 0° C. there is obtained 2-ethoxy-1-(4-bromo-2-fluoro-5-hydroxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone, m.p. 160°-161° C.

후처리

customduring 2 minutes
customat 0° C.

출처 및 근거

ORD 기록: ord-85621e2ba43c4bc697059f0c21e0eb3e
출처 데이터셋: uspto-grants-1989_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04812164

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