Potassium Carbonate → HCID 21271267, 화합물

HRID 1194008노트

반응식

HRID 1194008 반응식
[OH:1][C:2]1[CH:3]=[C:4]([C:7]([O:9][CH3:10])=[O:8])[S:5][CH:6]=1.I[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]1[O:23][N:22]=[C:21]([CH3:24])[CH:20]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:24][C:21]1[CH:20]=[C:19]([CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][O:1][C:2]2[CH:3]=[C:4]([C:7]([O:9][CH3:10])=[O:8])[S:5][CH:6]=2)[O:23][N:22]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 13277908Methyl 4-hydroxythiophene-2-carboxylateHCID 21271268HCID 21271268, 화합물

생성물 1

HCID 21271267HCID 21271267, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

6.42 g (40.60 mmol) of methyl 4-hydroxy-2-thiophenecarboxylate (XIa) and 11.88 g (38.67 mmol) of 5-(7-iodoheptyl)-3-methyl-isoxazole (IX) are heated under reflux with 5.34 g (40.60 mmol) of potassium carbonate (K2CO3) in 130 ml of anhydrous acetone for 8 hours. After the mixture has been left to stand overnight, it is concentrated, the residue is partitioned between 2N NaOH and ether and the aqueous phase is extracted several times with a total of 150 ml of ether. The organic phase is dried over sodium sulfate/active charcoal and evaporated.

후처리

  1. waitAfter the mixture has been left
  2. concentrationit is concentrated
  3. customthe residue is partitioned between 2N NaOH and ether
  4. extractionthe aqueous phase is extracted several times with a total of 150 ml of ether
  5. dry with materialThe organic phase is dried over sodium sulfate/active charcoal
  6. customevaporated

출처 및 근거

ORD 기록
ord-d1919189db3f431594790d2f33c6fc7a
출처 데이터셋
uspto-grants-1989_03
특허 번호
US04812472

반응 노트

불러오는 중…