Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → (2R,6R)-2-(2'-phenylethyl)-6-methyl-1,3-dioxan-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Benzenepropanal | HCID 7707 | — |
| 반응물 | 3-Hydroxybutanoic acid, (R)- | HCID 92135 | — |
| 반응물 | Pyridinium.p-toluenesulfonate | HCID 22033616 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (2R,6R)-2-(2'-phenylethyl)-6-methyl-1,3-dioxan-4-one | HCID 13741776 | 63.5% |
반응 단계
A mixture of (R)-3-hydroxybutanoic acid (7.8 g), 3-phenylpropionaldehyde (6.71 g) and pyridinium toluene-4-sulphonic acid (ca. 10 mmol %) in dichloromethane (300 ml) was stirred, under reflux, for 48 hours with removal of water. The reaction mixture was cooled to room temperature, washed three times with saturated sodium bicarbonate, dried (MgSO4) and evaporated under reduced pressure. The residue was crystallised from ether/pentane to give (2R,6R)-2-(2'-phenylethyl)-6-methyl-1,3-dioxan-4-one (7.0 g), m.p. 49.7°-50.9° C.; [α]DR.T. =15.2(c=1.05; CHCl3).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04812476 |
| 출처 데이터셋 | uspto-grants-1989_03 |
| ORD ID | ord-22f3e655f0634123b861e7ded464c1aa |
| 출처 메모 | uspto-grants-1989_03 |