Acetone → 3-Benzyl-4-fluorobenzaldehyde

HRID 1194035노트

반응식

HRID 1194035 반응식
[CH2:1]([C:8]1[CH:9]=[C:10]([CH:15]2OCC[O:16]2)[CH:11]=[CH:12][C:13]=1[F:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CC(C)=O.O>S(=O)(=O)(O)O.C(OCC)C>[CH2:1]([C:8]1[CH:9]=[C:10]([CH:11]=[CH:12][C:13]=1[F:14])[CH:15]=[O:16])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

6

반응물 3

HCID 180AcetoneHCID 962WaterHCID 138542792-(3-Benzyl-4-fluorophenyl)-1,3-dioxolane

생성물 1

HCID 138542803-Benzyl-4-fluorobenzaldehyde

시약·촉매·용매 2

HCID 1118Sulfuric Acid촉매HCID 3283Diethyl Ether용매

실험 절차

A mixture of 2-(3-benzyl-4-fluorophenyl)-1,3-dioxolane (0.7 h) acetone (10 cm3), water (1 cm3) and concentrated sulphuric acid (5 drops) was stirred for 16 hours. The reaction mixture was poured into diethyl ether and the organic layer washed with sodium bicarbonate solution, water and brine, then dried over anhydrous magnesium sulphate. Evaporation of the solvents under reduced pressure gave 3-benzyl-4-fluorobenzaldehyde (0.59 g), which was used without further purification.

후처리

  1. washthe organic layer washed with sodium bicarbonate solution, water and brine
  2. dry with materialdried over anhydrous magnesium sulphate
  3. customEvaporation of the solvents under reduced pressure

출처 및 근거

ORD 기록
ord-5aae20f4b9144c2ea455263f8863cee0
출처 데이터셋
uspto-grants-1989_03
특허 번호
US04812483

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