5-Aminoisoquinoline → 5-Amino-1,2,3,4-tetrahydroisoquinoline

HRID 1194100

반응식

HRID 1194100 반응식
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2.[H][H]>C(O)(=O)C.[Pt]=O>[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][NH:6][CH2:7]2

참가 물질

5

반응물 2

HCID 707665-AminoisoquinolineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 162174995-Amino-1,2,3,4-tetrahydroisoquinoline

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 176Acetic Acid용매

실험 절차

A solution of 5-aminoisoquinoline (20 g) in glacial acetic acid (500 ml) was shaken under hydrogen in the presence of a platinum oxide catalyst (2.0 g) at room temperature and approximately 345 kilopascals pressure until uptake of hydrogen stopped. The catalyst was removed by filtration and the filtrate was evaporated to a small volume under reduced pressure. Residual solvent was removed by co-evaporation with water, then isopropyl alcohol, and the resulting solid was recrystallized from isopropyl alcohol to give 5-amino-1,2,3,4-tetrahydroisoquinoline as a white solid, 19 g, m.p. 153°-154° C.

후처리

  1. customThe catalyst was removed by filtration
  2. customthe filtrate was evaporated to a small volume under reduced pressure
  3. customResidual solvent was removed by co-evaporation with water
  4. customisopropyl alcohol, and the resulting solid was recrystallized from isopropyl alcohol

출처 및 근거

ORD 기록
ord-8186bc04f14c47bcbe302433515f8a22
출처 데이터셋
uspto-grants-1989_03
특허 번호
US04812573

연결된 노트

불러오는 중…