Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1194152생성일: 2026년 10월 25일
Potassium Phosphate, Tribasic → 3-(3-methyl-4-methoxyphenyl)methyl-N-BOC-histidine methyl ester
https://huagongshe.com/reaction/1194152
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Methanesulfonic anhydride | HCID 81560 | — |
| 반응물 | N(alpha), N-(im)-Di-Boc-L-histidine methyl ester | HCID 10904703 | — |
| 반응물 | (4-Methoxy-3-methylphenyl)methanol | HCID 14457544 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-(3-methyl-4-methoxyphenyl)methyl-N-BOC-histidine methyl ester | HCID 18631280 | — |
반응 단계
A solution of 10.8 g methanesulfonic anhydride in 120 mL dichloromethane is chilled to -50° C. and treated dropwise with a solution of 9.4 g 3-methyl-4-methoxybenzyl alcohol, 10.8 mL diisopropylethylamine and 80 mL dichloromethane. The resulting solution is warmed to -25° C. over 30 min and treated dropwise with 20.0 g N,1-bis-BOC-histidine methyl ester dissolved in 125 mL dichloromethane. The mixture is then allowed to warm to 25° C. over 4 hr, stirring at this temperature 24 hr. The reaction mixture is poured into 700 mL 0.25M, pH=7 potassium phosphate buffer and the organic layer is separated, dried and evaporated. Chromatography on silica gel, eluting with chloroformmethanol (99:1) gives 3-(3-methyl-4-methoxyphenyl)methyl-N-BOC-histidine methyl ester as a gum. NMR (CDCl3) 1.43 (s,9H,t-Bu).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US04812462 |
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| 출처 데이터셋 | uspto-grants-1989_03 |
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| ORD ID | ord-f659c5288ab54b87980308e431266723 |
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| 출처 메모 | uspto-grants-1989_03 |
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