Bromine → HCID 15615543, 화합물
반응식
[CH3:1][N:2]([CH3:13])[C:3]([C:5]1[O:6][C:7]([C:10](=[O:12])[CH3:11])=[CH:8][CH:9]=1)=[O:4].[Br:14]Br>C(O)(=O)C>[CH3:13][N:2]([CH3:1])[C:3]([C:5]1[O:6][C:7]([C:10](=[O:12])[CH2:11][Br:14])=[CH:8][CH:9]=1)=[O:4]참가 물질
4
실험 절차
A mixture of 1.81 g. (0.01 mole) of N,N-dimethyl-5-acetylfuran-2-carboxamide, 1.59 g. (0.01 mole) of bromine and 40 ml. of glacial acetic acid was stirred at room temperature for 18 hours, and then the acetic acid was removed by evaporation in vacuo. The residue was partitioned between water and ethyl acetate and the layers were separated. The aqueous layer was further extracted with ethyl acetate, and the combined ethyl acetate solutions were washed with sodium bicarbonate solution followed by water, dried (Na2SO4) and evaporated in vacuo. This afforded 2.6 g. of the title compound as a solid.
후처리
- additionA mixture of 1.81 g
- customthe acetic acid was removed by evaporation in vacuo
- customThe residue was partitioned between water and ethyl acetate
- customthe layers were separated
- extractionThe aqueous layer was further extracted with ethyl acetate
- washthe combined ethyl acetate solutions were washed with sodium bicarbonate solution
- dry with materialdried (Na2SO4)
- customevaporated in vacuo
출처 및 근거
- ORD 기록
- ord-944df5bfcab44d2294ab2d8884307d1c
- 출처 데이터셋
- uspto-grants-1989_03
- 특허 번호
- US04814341
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