Imidazole → 3-(1H-Imidazol-1-yl)-1-(1H-indol-3-yl)propan-1-one

반응식

[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10](=[O:13])[CH:11]=[CH2:12])=[CH:2]1.[NH:14]1[CH:18]=[CH:17][N:16]=[CH:15]1>>[N:14]1([CH2:12][CH2:11][C:10]([C:3]2[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[NH:1][CH:2]=2)=[O:13])[CH:18]=[CH:17][N:16]=[CH:15]1

참가 물질

반응물 2

HCID 795Imidazole

HCID 15122794HCID 15122794, 화합물

생성물 1

HCID 212700593-(1H-Imidazol-1-yl)-1-(1H-indol-3-yl)propan-1-one수율 56.2%

실험 절차

By a similar procedure to that described in Example 1, 1-(1H-indol-3-yl)-1-prop-2-enone (0.4 g) was reacted with imidazole (0.8 g) to give the title compound (0.314 g), m.p. 194°-197°; λmax (EtOH) 242.5 nm (ε12,900) λinf 259 nm (ε9,090) λmax 299.5 nm (ε12,390).

출처 및 근거

ORD 기록: ord-31532b70e2fc45128b535801b8deded3
출처 데이터셋: uspto-grants-1989_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04814344

반응 노트

불러오는 중…