Imidazole → 3-(1H-Imidazol-1-yl)-1-(1H-indol-3-yl)propan-1-one

반응식

[CH3:1][N:2]([CH3:16])[CH2:3][CH2:4][C:5]([C:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[NH:9][CH:8]=1)=[O:6].[NH:17]1C=CN=[CH:18]1>>[N:2]1([CH2:3][CH2:4][C:5]([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][CH:8]=2)=[O:6])[CH:1]=[CH:18][N:17]=[CH:16]1

참가 물질

반응물 2

HCID 795Imidazole

HCID 327503-(3-Dimethylaminopropionyl)indole

생성물 1

HCID 212700593-(1H-Imidazol-1-yl)-1-(1H-indol-3-yl)propan-1-one

실험 절차

3-(Dimethylamino)-1-(1H-indol-3-yl)-1-propanone was converted to the methiodide (12.75 g) which was then reacted with imidazole (12.75 g) to give the title compound (4.67 g), m.p. 193°-197°; λmax (EtOH) 242.5 nm (ε11,130), λinf 257.5 nm (ε9,120), λmax 299 nm (ε12,420), identical with the material obtained in Example 2.

출처 및 근거

ORD 기록: ord-ab5bf2e4e4444631aece17efbf5af0e0
출처 데이터셋: uspto-grants-1989_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04814344

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