Thionyl Chloride → (S)-(-)-(3-Chloro-2-hydroxypropyl)trimethylammonium chloride

HRID 1194577노트

반응식

HRID 1194577 반응식
[Cl-:1].[OH:2][C@H:3]([CH2:9]O)[CH2:4][N+:5]([CH3:8])([CH3:7])[CH3:6].S(Cl)([Cl:13])=O>CN(C)C=O>[Cl-:13].[Cl:1][CH2:9][C@@H:3]([OH:2])[CH2:4][N+:5]([CH3:8])([CH3:7])[CH3:6]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 13668848(S)-2,3-Dihydroxy-N,N,N-trimethylpropan-1-aminium chloride

생성물 1

HCID 2793814(S)-(-)-(3-Chloro-2-hydroxypropyl)trimethylammonium chloride

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
100 °C

실험 절차

Moreover, the obtained (S)-2,3-dihydroxypropyltrimethylammonium chloride was suspended in 100 ml of dimethylformamide and then 22.57 g of thionyl chloride was added thereto at a tempareture from 5° to 10° C. After stirring for 20 minutes, it was heated for 5 hours at 100° C. Finally, after the reaction was completed and the reaction mixture was cooled to room temperature, it was evaporated to dryness and then the residue was washed with methylene chloride to give 30.20 g of (S)-3-chloro-2-hydroxypropyltrimethylammonium chloride.

후처리

  1. customfrom 5° to 10° C
  2. temperaturethe reaction mixture was cooled to room temperature
  3. customit was evaporated to dryness
  4. washthe residue was washed with methylene chloride

출처 및 근거

ORD 기록
ord-501095971757421a9354fc5a6bdb2e74
출처 데이터셋
uspto-grants-1989_03
특허 번호
US04814506

반응 노트

불러오는 중…