Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Iodide → 1-(Bromomethyl)-3-chloro-5-methylbenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Iodide | HCID 4875 | — |
| 반응물 | 3,5-Dimethylchlorobenzene | HCID 32887 | — |
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 촉매 | Benzoyl Peroxide | HCID 7187 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | 1-(Bromomethyl)-3-chloro-5-methylbenzene | HCID 12375549 | 109.1% |
반응 단계
A solution of 5-chloro-m-xylene (59.3 g) and dibenzoyl peroxide (5.0 g) in 1.13 L of benzene was heated at reflux. N-Bromosuccinimide (82.2 g) was added in portions over 15 minutes. Heating was continued for an additional 20 minutes until a negative potassium iodide reaction was observed. The reaction mixture was cooled, evaporated and then titurated with hexane (500 ml). The precipitated succinimide was removed by filtration and washed with additional hexane. Concentration afforded 101 g of crude 3-chloro-5-methylbenzyl bromide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04816469 |
| 출처 데이터셋 | uspto-grants-1989_03 |
| ORD ID | ord-1cf85b3a1f3445a68f29f1be99623e2a |
| 출처 메모 | uspto-grants-1989_03 |