2,2,5,5-tetramethyl cyclohexanone → 1,2,2,5,5-Pentamethylcyclohexan-1-ol
반응식
[CH3:1][C:2]1([CH3:11])[CH2:7][CH2:6][C:5]([CH3:9])([CH3:8])[CH2:4][C:3]1=[O:10].[CH3:12][Li]>CCOCC>[CH3:12][C:3]1([OH:10])[CH2:4][C:5]([CH3:9])([CH3:8])[CH2:6][CH2:7][C:2]1([CH3:11])[CH3:1]참가 물질
4
반응 조건
- 온도
- 0 °C
실험 절차
A solution of 26.4 g of 2,2,5,5-tetramethylcyclohexanone in 250 ml of ether is added dropwise at -20° C. to 102.8 ml of methyl lithium (2 molar in ether). After stirring at 0° C. for 2.5 hours, the mixture is poured into ice/1N hydrochloric acid and extracted with ether. The organic phase is washed with water, dried and evaporated. The residue is distilled in a water-jet vacuum. There are obtained 22.6 g of 1,2,2,5,5-pentamethylcyclohexanol as a colorless liquid, b.p. 81°-87° C./17 mm.
후처리
- extractionextracted with ether
- washThe organic phase is washed with water
- customdried
- customevaporated
- distillationThe residue is distilled in a water-jet vacuum
출처 및 근거
- ORD 기록
- ord-e85ce6c2bc7a42a69ebf33c5762475e2
- 출처 데이터셋
- uspto-grants-1989_03
- 특허 번호
- US04816476
반응 노트
불러오는 중…