Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → Ganciclovir Di-O-acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | 9-[[2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine hydrate | HCID 136078993 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | Ganciclovir Di-O-acetate | HCID 135459822 | — |
반응 단계
A mixture of 205 mg (0.75 mmole) of 9-(1,3-dihydroxy-2-propoxymethyl)guanine monohydrate, 1.5 ml of acetic anhydride, 6 ml of dry dimethylformamide, and 1.5 ml of dry pyridine was stirred at room temperature under a drying tube for 4 days. Then the mixture was diluted with 15 ml of Et2O. The solid was collected on a filter and washed with Et2O. After recrystallization from 2-methoxyethanol, yield of colorless crystals=149 mg (59% ), m.p. 239°-240°. The material was homogenous by TLC (9:1 CHCl3 ---MeOH), and NMR confirmed the assigned structure.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04816447 |
| 출처 데이터셋 | uspto-grants-1989_03 |
| ORD ID | ord-5e197afe03dd42ff8cb4487d27e480bd |
| 출처 메모 | uspto-grants-1989_03 |