Acetic Acid → 2,3-Dihydro-5-benzofuranacetic acid

HRID 1194815노트

반응식

HRID 1194815 반응식
[O:1]1[C:5]2[CH:6]=[CH:7][C:8](CC(N3CCOCC3)=S)=[CH:9][C:4]=2[CH2:3][CH2:2]1.[C:19]([OH:22])(=[O:21])[CH3:20].S(=O)(=O)(O)O>O>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:20][C:19]([OH:22])=[O:21])=[CH:9][C:4]=2[CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 1118Sulfuric AcidHCID 137043802-(2,3-Dihydrobenzofuran-5-yl)-1-morpholinoethanethione

생성물 1

HCID 27374552,3-Dihydro-5-benzofuranacetic acid

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

2,3-dihydrobenzofuran-5-ylthioacetic acid morpholide (5.0 g) was heated at reflux in a solution of acetic acid (20 ml), concentrated sulfuric acid (3.0 ml) and water (4.5 ml). After 3 hours the reaction mixture was cooled and added to water. The product was extracted with ethyl acetate and the combined extracts washed five times with water. The organic solution was then extracted with aqueous saturated sodium bicarbonate solution. The aqueous solution was then acidified and extracted with ethyl acetate. The combined extracts were dried over sodium sulfate and evaporated to give a residue which was recrystallized from acetone/hexane to give 2,3-dihydrobenzofuran-5-ylacetic acid, m.p. --96°-98° C.

후처리

  1. temperatureAfter 3 hours the reaction mixture was cooled
  2. extractionThe product was extracted with ethyl acetate
  3. washthe combined extracts washed five times with water
  4. extractionThe organic solution was then extracted with aqueous saturated sodium bicarbonate solution
  5. extractionextracted with ethyl acetate
  6. dry with materialThe combined extracts were dried over sodium sulfate
  7. customevaporated
  8. customto give a residue which
  9. customwas recrystallized from acetone/hexane

출처 및 근거

ORD 기록
ord-089a6fa977f143e6acab8517348086b4
출처 데이터셋
uspto-grants-1989_03
특허 번호
US04816473

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