Water → HCID 14865027, 화합물

HRID 1194871노트

반응식

HRID 1194871 반응식
[CH:1]1([CH2:4][O:5]/[N:6]=[C:7](/[C:13]2[N:14]=[C:15]([NH:18]C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[S:16][CH:17]=2)\[C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:3][CH2:2]1.O>C(O)=O>[CH2:11]([O:10][C:8](=[O:9])/[C:7](/[C:13]1[N:14]=[C:15]([NH2:18])[S:16][CH:17]=1)=[N:6]\[O:5][CH2:4][CH:1]1[CH2:2][CH2:3]1)[CH3:12]

참가 물질

4

반응물 2

HCID 962WaterHCID 13269245HCID 13269245, 화합물

생성물 1

HCID 14865027HCID 14865027, 화합물수율 93%

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

Ethyl (Z)-2-cyclopropylmethoxyimino-2-(2-tritylaminothiazol-4-yl)acetate (2.39 g) was dissolved in 98% formic acid (18.7 ml), water (5.6 ml) was added, and the mixture vigorously stirred. After 6 h the solvents were evaporated, toluene added to the residue and the process repeated. This was done twice more. The residual solid was chromatographed on silica to give the title compound as a white solid (1.17 g), νmax (Nujol) 3440, 3250, 3120, 1720, and 1620 cm-1 ; δH (CDCl3) inter alia 1.35 (3H, t, J 7 Hz), 4.0 (2H, d, J 7 Hz), 4.37 (2H, q, J 7 Hz), 5.4 (2H, broad s, exch. D2O), and 6.67 (1H, s).

후처리

  1. customAfter 6 h the solvents were evaporated
  2. additiontoluene added to the residue
  3. customThe residual solid was chromatographed on silica

출처 및 근거

ORD 기록
ord-7952a0d63317461b9b87aa4b7f48ac6e
출처 데이터셋
uspto-grants-1989_03
특허 번호
US04816452

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