Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triphenylphosphine → ethyl (2Z)-2-(4-oxocyclohexyl)oxyimino-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | Potassium Bromide | HCID 253877 | — |
| 반응물 | Azodicarboxylic acid dimethyl ester | HCID 351621 | — |
| 반응물 | 4-Hydroxycyclohexanone | HCID 543706 | — |
| 반응물 | (Z)-Ethyl 2-(hydroxyimino)-2-(2-(tritylamino)thiazol-4-yl)acetate | HCID 6410761 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | ethyl (2Z)-2-(4-oxocyclohexyl)oxyimino-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetate | HCID 88627796 | — |
반응 단계
4-Hydroxycyclohexanone (570 mg; J. B. Aldersley, G. N. Burkhardt, A. E. Gillam, and N. C. Hindley, J. Chem. Soc., 1940, 10) ethyl 2-(2-tritylaminothiazol-4-yl)-(Z)-2-hydroxyiminoacetate (1.37 g) and triphenyl-phosphine (860 mg) in anhydrous benzene (9 ml) were allowed to react with dimethyl azodicarboxylate (0.40 ml) as described in Example 67c except the reaction time was 14 days. Workup and chromatography gave the title compound (158 mg), νmax (KBr) 3390, 1737, 1710, 1596, 1585, 1529, and 1491cm-1 ; δH (CDCl3) 1.33 (3H, t, J 7Hz), 2.01, 2.31, and 2.55 (8H, 3m), 4.36 (2H, q, J 7z), 4.73 (1H, m), 6.52 (1H, s), 6.97 (1H, brs, D2O exch.), and 7.30 (15H, br s).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04816452 |
| 출처 데이터셋 | uspto-grants-1989_03 |
| ORD ID | ord-b74806e46eb14c82a472f13ae452f449 |
| 출처 메모 | uspto-grants-1989_03 |