2-(4-Methoxyphenoxy)ethylamine → 2-{2-Hydroxy-3-[2-(4-methoxyphenoxy)ethylamino]-propoxy}-5-(2-methoxyethoxy)benzonitrile

HRID 1195081노트

반응식

HRID 1195081 반응식
[O:1]1[CH2:18][CH:2]1[CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][O:16][CH3:17])=[CH:9][C:6]=1[C:7]#[N:8].[CH3:19][O:20][C:21]1[CH:30]=[CH:29][C:24]([O:25][CH2:26][CH2:27][NH2:28])=[CH:23][CH:22]=1>C(O)C>[OH:1][CH:2]([CH2:18][NH:28][CH2:27][CH2:26][O:25][C:24]1[CH:29]=[CH:30][C:21]([O:20][CH3:19])=[CH:22][CH:23]=1)[CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][O:16][CH3:17])=[CH:9][C:6]=1[C:7]#[N:8]

참가 물질

4

반응물 2

HCID 17977932-(4-Methoxyphenoxy)ethylamineHCID 13313566HCID 13313566, 화합물

생성물 1

HCID 133135672-{2-Hydroxy-3-[2-(4-methoxyphenoxy)ethylamino]-propoxy}-5-(2-methoxyethoxy)benzonitrile

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2.4 g of 2-(2,3-epoxypropoxy)-5-(2-methoxyethoxy)-benzonitrile and 8.35 g of 2-(4-methoxyphenoxy)ethylamine are dissolved in 30 ml of ethanol, the solvent is then evaporated and the resulting mixture stirred for 1 hour at 70°. The reaction melt is then dissolved in ether and allowed to crystallize under cooling. Purification is effected by recrystallization in benzene. The title compound is obtained (M.P. 95°-97°).

후처리

  1. customthe solvent is then evaporated
  2. dissolutionThe reaction melt is then dissolved in ether
  3. customto crystallize
  4. temperatureunder cooling
  5. customPurification
  6. customis effected by recrystallization in benzene

출처 및 근거

ORD 기록
ord-472781582779427499382d0354e23d27
출처 데이터셋
uspto-grants-1989_03
특허 번호
US04816604

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