Potassium Hydroxide → HCID 6476762, 화합물

HRID 1195147노트

반응식

HRID 1195147 반응식
[CH3:1]/[C:2](/[CH2:6][CH2:7][CH:8]=[C:9]([CH3:11])[CH3:10])=[CH:3]\[CH2:4][SH:5].[OH-].[K+].Cl[CH:15]([C:22]1[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][C:23]=1[Cl:29])[CH2:16][N:17]1[CH:21]=[CH:20][N:19]=[CH:18]1>CO.C(O)C>[Cl:29][C:23]1[CH:24]=[C:25]([Cl:28])[CH:26]=[CH:27][C:22]=1[CH:15]([S:5][CH2:4]/[CH:3]=[C:2](\[CH3:1])/[CH2:6][CH2:7][CH:8]=[C:9]([CH3:11])[CH3:10])[CH2:16][N:17]1[CH:21]=[CH:20][N:19]=[CH:18]1

참가 물질

6

반응물 3

HCID 14797Potassium HydroxideHCID 6365572(E)-3,7-Dimethylocta-2,6-diene-1-thiolHCID 124607821-[2-Chloro-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole

생성물 1

HCID 6476762HCID 6476762, 화합물수율 54.6%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 887Methanol용매

실험 절차

To a stirred solution of (E)-3,7-dimethylocta-2,6-dienylmercaptan (1.00 g=5.9 mmol) in methanol (40 ml) was added potassium hydroxide (0.33 g=5.8 mmol) and 1-chloro-1-(2,4-dichlorophenyl)-2-(1H-imidazole-1-yl)ethane (1.62 g=5.9 mmol) in ethanol at room temperature, and then the reaction mixture was refluxed for 90 minutes. After cooling, the methanol was evaporated, and then the residue was diluted with chloroform. The chloroform layer was washed with water, followed by drying over anhydrous sodium sulfate. Concentration followed by column chromatography on silica gel (ethyl acetate:hexane=2:3) gave 1.32 g of Compound 10 as a colorless oil.

후처리

  1. temperaturethe reaction mixture was refluxed for 90 minutes
  2. temperatureAfter cooling
  3. customthe methanol was evaporated
  4. additionthe residue was diluted with chloroform
  5. washThe chloroform layer was washed with water
  6. dry with materialby drying over anhydrous sodium sulfate
  7. concentrationConcentration

출처 및 근거

ORD 기록
ord-10baf165870b4d5da61e6c5298cf9bdb
출처 데이터셋
uspto-grants-1992_05
특허 번호
US05110826

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