Thionyl Chloride → 9-Acridinecarbonyl chloride

반응식

O.[CH:2]1[C:15]2[C:6](=[N:7][C:8]3[C:13]([C:14]=2[C:16]([OH:18])=O)=[CH:12][CH:11]=[CH:10][CH:9]=3)[CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:21])=O>>[CH:2]1[C:15]2[C:6](=[N:7][C:8]3[C:13]([C:14]=2[C:16]([Cl:21])=[O:18])=[CH:12][CH:11]=[CH:10][CH:9]=3)[CH:5]=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 162116879-Acridinecarboxylic Acid Hydrate

생성물 1

HCID 6099609-Acridinecarbonyl chloride

실험 절차

A mixture of 9-acridinecarboxylic acid hydrate (7.3 g, 30 mmole), and thionyl chloride (50 ml, 0.685 mole) was heated at reflux in a round bottom flask equipped with a reflux condenser, a drying tube, and a stirring bar. The reaction mixture was heated further for one hour after the dissolution occurred, the cooled and evaporated to remove any excess thionyl chloride. The residue was directly utilized in the subsequent reaction without further purification.

후처리

temperaturewas heated
temperatureat reflux in a round bottom flask
customequipped with a reflux condenser, a drying tube, and a stirring bar
temperatureThe reaction mixture was heated further for one hour
dissolutionafter the dissolution
temperaturethe cooled
customevaporated
customto remove any excess thionyl chloride
customThe residue was directly utilized in the subsequent reaction without further purification

출처 및 근거

ORD 기록: ord-c1e5d79b123447f39f0a5c1b1a8aec1b
출처 데이터셋: uspto-grants-1992_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05110932

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