Methanol → Methyl 2-[[3-(trifluoromethyl)phenyl]amino]benzoate

HRID 1195872

반응식

[F:1][C:2]([F:20])([F:19])[C:3]1[CH:4]=[C:5]([NH:9][C:10]2[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=2[C:12]([OH:14])=[O:13])[CH:6]=[CH:7][CH:8]=1.S(=O)(=O)(O)O.[CH3:26]O>>[F:1][C:2]([F:19])([F:20])[C:3]1[CH:4]=[C:5]([NH:9][C:10]2[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=2[C:12]([O:14][CH3:26])=[O:13])[CH:6]=[CH:7][CH:8]=1

참가 물질

반응물 3

HCID 887Methanol

HCID 1118Sulfuric Acid

HCID 3371Flufenamic Acid

생성물 1

HCID 200813Methyl 2-[[3-(trifluoromethyl)phenyl]amino]benzoate수율 71%

실험 절차

Reaction of 2-[[3-(trifluoromethyl)phenyl]amino] benzoic acid with methanol and sulfuric acid according to the procedure of Example 26 gives a 71% yield of 2-[[3-(trifluoromethyl)phenyl]amino]benzoic acid, methyl ester as a colorless oil.

출처 및 근거

ORD 기록: ord-7004dd01d3034ea8a81d4fcefd8b1833
출처 데이터셋: uspto-grants-1992_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05112846

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