Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisobutylaluminum hydride → (2,5-Dimethylfuran-3-yl)methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisobutylaluminum hydride | HCID 14487 | — |
| 반응물 | 3-Furancarboxylic acid, 2,5-dimethyl-, methyl ester | HCID 80248 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (2,5-Dimethylfuran-3-yl)methanol | HCID 10396847 | 63.6% |
반응 단계
To a stirred solution of 3-carbomethoxy-2,5-dimethylfuran (2.5 g, 16.2 mmol) in methylene chloride (distilled from CaH) at -20° C., under N2, was added 2.5 eq of DIBAL (1M in CH2Cl2). After 1 h, the dry ice/acetonitrile bath was removed and 60 mL of 10% HCl was added dropwise. The organic layer was separated, dried over MgSO4, and evaporated. The residue was chromatographed (silica gel, 60% ether/hexane) to yield 1.3 g of 2,5-dimethyl-3- hydroxymethylfuran.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05112848 |
| 출처 데이터셋 | uspto-grants-1992_05 |
| ORD ID | ord-f6ac591abb914eab81323a78a007bd58 |
| 출처 메모 | uspto-grants-1992_05 |