Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Dimethyl 2-(3-fluoro-naphthacene-5,12-dionyl)-malonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Dimethyl malonate | HCID 7943 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2,3-Difluoronaphthacene-5,12-dione | HCID 20089834 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | Dimethyl 2-(3-fluoro-naphthacene-5,12-dionyl)-malonate | HCID 20089823 | — |
반응 단계
1 g (3.4 mmol) of 2,3-difluoro-naphthacene-5,12-dione, 0.94 g (6.8 mmol) of potassium carbonate, 0.89 g (6.8 mmol) of dimethyl malonate and 20 ml of DMSO are stirred at 50° C. for 22 hours. The mixture is poured onto dilute hydrochloric acid and extracted with THF/toluene. The organic phase is washed with water, dried over sodium sulfate and evaporated. The product is purified by chromatography over silica gel (mobile phase: 1% acetone/99% CH2Cl2); yield 1.25 g (91%); melting point 225°-230° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05112977 |
| 출처 데이터셋 | uspto-grants-1992_05 |
| ORD ID | ord-5ebc7f3d85fa45e2a39b1aade1d3c979 |
| 출처 메모 | uspto-grants-1992_05 |