참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethyl malonate | HCID 7943 | — |
| 반응물 | Methyl (E)-4-Chloro-3-methoxy-2-butenoate | HCID 6364655 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5,5-bis(methoxycarbonyl)-3-methoxy-2E-pentenoic acid methyl ester | HCID 11436868 | — |
반응 단계
66 g (0.5 mol) of malonic acid dimethyl ester was placed in 250 ml of N,N'-dimethylformamide. 27.8 g (0.5 mol) of sodium methylate was added at 20° C.; 10 minutes later 41.6 g (0.25 mol) of 4-chloro-3-methoxy-2E-butenoic acid methyl ester was added within 5 minutes. It was stirred for 2 hours at 20° C. Then 10.8 g (0.2 mol) of sodium methylate was added once more. After stirring for 15 hours at 20° C. it was distilled off. After working up according to Example (a) 53.8 g (81 percent) of the title compound, with a purity of 98 percent (GC), was obtained. Data for the title compound was:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05113012 |
|---|
| 출처 데이터셋 | uspto-grants-1992_05 |
|---|
| ORD ID | ord-ed63ff36add5402389411e01e7d6ae69 |
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| 출처 메모 | uspto-grants-1992_05 |
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