Ethyl bromoacetate → HCID 21671609, 화합물

HRID 1196421노트

반응식

HRID 1196421 반응식
[CH2:1]([C:5]1[CH2:10][CH2:9][CH2:8][C:7](=[O:11])[CH:6]=1)[CH2:2][CH2:3][CH3:4].C([N-]C(C)C)(C)C.[Li+].Br[CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23].C(CC1C(=O)C=C(C)CC1)(OCC)=O>C1COCC1>[C:22]([CH2:21][CH:8]1[C:7](=[O:11])[CH:6]=[C:5]([CH2:1][CH2:2][CH2:3][CH3:4])[CH2:10][CH2:9]1)([O:24][CH2:25][CH3:26])=[O:23]

참가 물질

6

반응물 4

HCID 7748Ethyl bromoacetateHCID 2390953-Butylcyclohex-2-en-1-oneHCID 2724682Lithium diisopropylamideHCID 216716086-(Carbethoxymethyl)-3-methyl-2-cyclohexen-1-one

생성물 1

HCID 21671609HCID 21671609, 화합물수율 83.5%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

The reaction of 3-n-butyl-2-cyclohexen-1-one (3.0 g, 19.7 mmoles) in 10 ml of THF with lithium diisopropylamide (2.17 mmoles) followed by ethyl bromoacetate (3.96 g, 23.6 mmoles) in 10 ml of THF, at -78° C. under argon, was conducted in a similar manner to the synthesis of 6-(carbethoxymethyl)-3-methyl-2-cyclohexen-1-one described in Example II, and a yield of 3.92 g (83%) of 6-(carbethoxymethyl)-3-n-butyl-2-cyclohexen-1-one was obtained.

출처 및 근거

ORD 기록
ord-b392d21db49140da94f5a98682872e59
출처 데이터셋
uspto-grants-1992_05
특허 번호
US05114493

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