6-(Carbethoxymethyl)-3-phenyl-2-cyclohexen-1-one → 6-(Carbethoxymethyl)-3-phenylcyclohexanone

HRID 1196423노트

반응식

HRID 1196423 반응식
[C:1]([CH2:6][CH:7]1[C:12](=[O:13])[CH:11]=[C:10]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:9][CH2:8]1)([O:3][CH2:4][CH3:5])=[O:2]>[Pd].C(OCC)(=O)C>[C:1]([CH2:6][CH:7]1[C:12](=[O:13])[CH2:11][CH:10]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:9][CH2:8]1)([O:3][CH2:4][CH3:5])=[O:2]

참가 물질

4

반응물 1

HCID 216716106-(Carbethoxymethyl)-3-phenyl-2-cyclohexen-1-one

생성물 1

HCID 198983466-(Carbethoxymethyl)-3-phenylcyclohexanone수율 71%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

6-(Carbethoxymethyl)-3-phenyl-2-cyclohexen-1-one (2.11 g) was added to a mixture of 0.2 g of 10% palladium on carbon in 30 ml of ethyl acetate. The reaction mixture was hydrogenated under a hydrogen atmosphere (maximum pressure 45 psi) for 41 hours. The mixture was filtered through celite, and the solvent was removed under reduced pressure. The recovered crude oil product was purified by chromatography on silica gel eluted with 5% ethyl acetate in hexane to provide 1.5 g (71%) of 6-(carbethoxymethyl)-3-phenylcyclohexanone.

후처리

  1. customfor 41 hours
  2. filtrationThe mixture was filtered through celite
  3. customthe solvent was removed under reduced pressure
  4. customThe recovered crude oil product
  5. customwas purified by chromatography on silica gel
  6. washeluted with 5% ethyl acetate in hexane

출처 및 근거

ORD 기록
ord-7c46a809bee84b7e9caf67792ad49c77
출처 데이터셋
uspto-grants-1992_05
특허 번호
US05114493

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