Thionyl Chloride → 4-(4-Trifluoromethylbenzyloxy)-2-chloromethylpyridine

HRID 1196623노트

반응식

HRID 1196623 반응식
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:18]=[CH:17][C:6]([CH2:7][O:8][C:9]2[CH:14]=[CH:13][N:12]=[C:11]([CH2:15]O)[CH:10]=2)=[CH:5][CH:4]=1.S(Cl)([Cl:23])=O>ClCCl>[F:1][C:2]([F:20])([F:19])[C:3]1[CH:18]=[CH:17][C:6]([CH2:7][O:8][C:9]2[CH:14]=[CH:13][N:12]=[C:11]([CH2:15][Cl:23])[CH:10]=2)=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 144259724-(4-Trifluoromethylbenzyloxy)-2-hydroxymethylpyridine

생성물 1

HCID 144259864-(4-Trifluoromethylbenzyloxy)-2-chloromethylpyridine

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

2.2 g (7.8 mmol) of the title compound from Example 3 are dissolved in 50 ml of anhydrous dichloromethane and a solution of 2 ml of thionyl chloride in 6 ml of dichloromethane is added dropwise at -10° C. The mixture is warmed to room temperature, stirred for 30 minutes more, and concentrated. The crystalline residue is brought to crystallization using diisopropyl ether and dried using an oilpump, m.p. 133°-135° C.

후처리

  1. concentrationconcentrated
  2. customThe crystalline residue is brought to crystallization
  3. customdried

출처 및 근거

ORD 기록
ord-a9a3fc14b80044d4ada986a19f0862a4
출처 데이터셋
uspto-grants-1992_05
특허 번호
US05114955

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