4-(4-Trifluoromethylbenzyloxy)-2-chloromethylpyridine → 2-[4-(4-Trifluoromethylbenzyloxy)-2-picolylmercapto]-1H-thieno[3,4-d]imidazole dihydrochloride

HRID 1196624노트

반응식

HRID 1196624 반응식
[SH:1][C:2]1[NH:3][C:4]2[C:5](=[CH:7][S:8][CH:9]=2)[N:6]=1.[F:10][C:11]([F:29])([F:28])[C:12]1[CH:27]=[CH:26][C:15]([CH2:16][O:17][C:18]2[CH:23]=[CH:22][N:21]=[C:20]([CH2:24][Cl:25])[CH:19]=2)=[CH:14][CH:13]=1>C(O)C>[ClH:25].[ClH:25].[F:29][C:11]([F:10])([F:28])[C:12]1[CH:27]=[CH:26][C:15]([CH2:16][O:17][C:18]2[CH:23]=[CH:22][N:21]=[C:20]([CH2:24][S:1][C:2]3[NH:6][C:5]4=[CH:7][S:8][CH:9]=[C:4]4[N:3]=3)[CH:19]=2)=[CH:14][CH:13]=1

참가 물질

4

반응물 2

HCID 144259864-(4-Trifluoromethylbenzyloxy)-2-chloromethylpyridineHCID 178527818HCID 178527818, 화합물

생성물 1

HCID 198989772-[4-(4-Trifluoromethylbenzyloxy)-2-picolylmercapto]-1H-thieno[3,4-d]imidazole dihydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
60 °C

실험 절차

0.625 g (4 mmol) of 2-mercaptothieno[3,4-d]imidazole are added at 25° C. to 1.35 g (4 mmol) of the title compound from Example 4 in 50 ml of ethanol, and the mixture is stirred at 60° C. for 1.5 hours. The reaction mixture is concentrated in vacuo, and the residue is treated with acetone, filtered off with suction, washed with acetone and dried in vacuo, m.p. 180°-182° C.

후처리

  1. concentrationThe reaction mixture is concentrated in vacuo
  2. additionthe residue is treated with acetone
  3. filtrationfiltered off with suction
  4. washwashed with acetone
  5. customdried in vacuo, m.p. 180°-182° C.

출처 및 근거

ORD 기록
ord-b3d8160494eb43e98587a971b3517321
출처 데이터셋
uspto-grants-1992_05
특허 번호
US05114955

반응 노트

불러오는 중…