Methanol → Methyl 2-(2-Aminoacetamido)Acetate

HRID 1196812

반응식

HRID 1196812 반응식
[NH2:1][CH2:2][C:3]([NH:5][CH2:6][C:7]([OH:9])=[O:8])=[O:4].S(Cl)(Cl)=O.[CH3:14]O>>[NH2:1][CH2:2][C:3]([NH:5][CH2:6][C:7]([O:9][CH3:14])=[O:8])=[O:4]

참가 물질

4

반응물 3

HCID 887MethanolHCID 11163GlycylglycineHCID 24386Thionyl Chloride

생성물 1

HCID 3248350Methyl 2-(2-Aminoacetamido)Acetate

실험 절차

2.5 g (19 mmoles) of Gly-Gly-OH was suspended in 25 mL of dry methanol. Two equivalents of thionyl chloride were added, and the suspension stirred to dissolution. The mixture was allowed to sit at room temperature overnight. The solvent was removed under vacuum, the residue taken up in a minimum of methanol, and anhydrous ether added to effect crystallization. Yield 3.2 g (92%). M.P. 146°-146° C. 1H-NMR (DMSO) 3.6 (s, 3H OMe), 3.8 and 3.9 (d, 2H, Gly α-H's).

후처리

  1. customThe solvent was removed under vacuum
  2. additionadded to effect crystallization

출처 및 근거

ORD 기록
ord-fc8851893076401a9a5849d488c88b6c
출처 데이터셋
uspto-grants-1992_05
특허 번호
US05116741

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