Dimethylamine → (3-(Dimethylamino)propyl)triphenylphosphonium bromide hydrobromide

HRID 1196987노트

반응식

HRID 1196987 반응식
[BrH:1].[Br-].[Br:3][CH2:4][CH2:5][CH2:6][P+:7]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[CH3:26][NH:27][CH3:28]>C(O)C>[BrH:3].[Br-:1].[CH3:26][N:27]([CH3:28])[CH2:4][CH2:5][CH2:6][P+:7]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 674DimethylamineHCID 19897085(3-Bromopropyl)-triphenylphosphonium bromide hydrobromide

생성물 1

HCID 23651404(3-(Dimethylamino)propyl)triphenylphosphonium bromide hydrobromide

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Then, 100.0 g of (3-bromopropyl)-triphenylphosphonium bromide hydrobromide is suspended in 500 ml of ethanol and 300 ml of 50% aqueous dimethylamine solution is added thereto. After heating the mixture at reflux for 10 minutes, the mixture is allowed to stand for cooling. The solvent is distilled away under reduced pressure and the resultant crude product is recrystallized from ethanol to obtain 64.0 g of the desired product having the physicochemical properties as identified in Table 8.

후처리

  1. temperatureAfter heating the mixture
  2. temperatureat reflux for 10 minutes
  3. temperaturefor cooling
  4. distillationThe solvent is distilled away under reduced pressure
  5. customthe resultant crude product is recrystallized from ethanol

출처 및 근거

ORD 기록
ord-a8437e3468174024ae8d418037873a05
출처 데이터셋
uspto-grants-1992_05
특허 번호
US05116863

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