1H-Indene, 2-bromo- → 2-Neopentylindene
반응식
Br[C:2]1[CH2:3][C:4]2[C:9]([CH:10]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2.[CH2:11]([Mg]Cl)[C:12]([CH3:15])([CH3:14])[CH3:13]>C1COCC1.Cl[Ni](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[CH2:11]([C:2]1[CH2:3][C:4]2[C:9]([CH:10]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2)[C:12]([CH3:15])([CH3:14])[CH3:13]참가 물질
5
실험 절차
To a mixture of 2-bromoindene (7.5 g, 39 mmol) and 2.5 g of NiCl2(PPh3)2 in 150 mL of THF was added over 1 hour 50 mL of neopentyl magnesium chloride (1.0 M in THF; 50 mmol). The mixture was stirred overnight and then quenched by adding 150 mL of 1.0 M aqueous hydrochloric acid. The product was isolated and purified (hexanes/silica) as for 2-benzyl-indene. Yield: 4.75 g, 66 percent
후처리
- customquenched
- additionby adding 150 mL of 1.0 M aqueous hydrochloric acid
- customThe product was isolated
- custompurified (hexanes/silica) as for 2-benzyl-indene
출처 및 근거
- ORD 기록
- ord-d016d5953a644d638a4f6edb144b58b4
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07098356B2
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