2,6-Dichlorophenol → Phenol, 2,6-dichloro-4-fluoro-

HRID 1197127

반응식

HRID 1197127 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[OH:9].[F:10][N+]1C(C(Cl)(Cl)Cl)=CC=CC=1Cl>ClC(Cl)CCl>[F:10][C:6]1[CH:7]=[C:2]([Cl:1])[C:3]([OH:9])=[C:4]([Cl:8])[CH:5]=1

참가 물질

4

반응물 2

HCID 68992,6-DichlorophenolHCID 11078230N-fluoro-2-chloro-6-(trichloromethyl) pyridinium

생성물 1

HCID 94950Phenol, 2,6-dichloro-4-fluoro-

시약·촉매·용매 1

HCID 65741,1,2-Trichloroethane용매

반응 조건

온도
55 °C

실험 절차

A mixture of 082 g of 2,6-dichlorophenol, 1.67 g of N-fluoro-2-chloro-6-(trichloromethyl) pyridinium rfluoroborate, and 40 ml of 1,1,2-trichloroethane was placed in a 100 ml 3-necked round bottomed flask equipped with a magnetic stirring bar, a thermometer, and a reflux condenser. The mixture was heated to 55° C. and allowed to react at that temperature for 8 hours under nitrogen. The mixture was then allowed to cool. Analysis by standardized gas-liquid chromatography using a mass spectrometer detector indicated that the title product was present in 24 percent conversion. The product identity was confirmed by its known 19F and 1H NMR spectra.

후처리

  1. customwas placed in a 100 ml 3-necked round bottomed flask
  2. customequipped with a magnetic stirring bar
  3. customto react at that temperature for 8 hours under nitrogen
  4. temperatureto cool

출처 및 근거

ORD 기록
ord-452532e5bdb94482bb2780cdd21dd7f2
출처 데이터셋
uspto-grants-1992_05
특허 번호
US05116982

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