2-(Hex-5-ynyl)malonic acid → 7-Octynoic acid
반응식
[CH2:1]([CH:7](C(O)=O)[C:8]([OH:10])=[O:9])[CH2:2][CH2:3][CH2:4][C:5]#[CH:6]>C(#N)C>[C:8]([OH:10])(=[O:9])[CH2:7][CH2:1][CH2:2][CH2:3][CH2:4][C:5]#[CH:6]참가 물질
3
실험 절차
A mixture of 2-(hex-5-ynyl)malonic acid (2.2 g) and cuprous oxide (60 mg) in dry acetonitrile (40 ml) was stirred and refluxed, under nitrogen, for 6 hours. The solvent was removed in vacuo. 5% Aqueous hydrochloric acid was added and the aqueous mixture was extracted with diethyl ether. The ethereal extracts were dried over anhydrous magnesium sulphate and the solvent was removed in vacuo. Oct-7-ynoic acid was obtained as an oil (1.5 g) and was used without further purification.
후처리
- temperaturerefluxed, under nitrogen, for 6 hours
- customThe solvent was removed in vacuo
- addition5% Aqueous hydrochloric acid was added
- extractionthe aqueous mixture was extracted with diethyl ether
- dry with materialThe ethereal extracts were dried over anhydrous magnesium sulphate
- customthe solvent was removed in vacuo
출처 및 근거
- ORD 기록
- ord-be8fb9c6dfd74b03bf3a33971a125ced
- 출처 데이터셋
- uspto-grants-1992_05
- 특허 번호
- US05116862
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