Ammonium Chloride → 3,3-Di-(benzylthiomethyl)hexan-2-ol

HRID 1197366노트

반응식

HRID 1197366 반응식
[CH2:1]([S:8][CH2:9][C:10]([CH2:16][S:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)([CH2:13][CH2:14][CH3:15])[CH:11]=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:25][Mg]I.[Cl-].[NH4+]>C(OCC)C>[CH2:18]([S:17][CH2:16][C:10]([CH2:9][S:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)([CH2:13][CH2:14][CH3:15])[CH:11]([OH:12])[CH3:25])[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

참가 물질

5

반응물 3

HCID 25517Ammonium ChlorideHCID 193734152,2-Di(benzylthiomethyl)pentanalHCID 178418373HCID 178418373, 화합물

생성물 1

HCID 193733193,3-Di-(benzylthiomethyl)hexan-2-ol

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

A solution of 2,2-di-(benzylthiomethyl)pentanal (3.54 g) in dry diethyl ether was added dropwise to a stirred solution of methyl magnesium iodide [prepared from methyl iodide (1.2 ml) and magnesium (0.48 g)] in dry diethyl ether (60 ml). The reaction mixture was refluxed for 2 hours and then cooled. Saturated aqueous ammonium chloride solution was added. The mixture was stirred for 30 minutes and extracted with diethyl ether. The ethereal extracts were dried over anhydrous magnesium sulphate and the solvent was removed in vacuo. 3,3-Di-(benzylthiomethyl)hexan-2-ol was obtained as a yellow oil (1.7 g)

후처리

  1. temperatureThe reaction mixture was refluxed for 2 hours
  2. temperaturecooled
  3. extractionextracted with diethyl ether
  4. dry with materialThe ethereal extracts were dried over anhydrous magnesium sulphate
  5. customthe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-8d4f45132f0b4e6da6f02ffd569a926c
출처 데이터셋
uspto-grants-1992_05
특허 번호
US05116862

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