Aniline → HCID 15022346, 화합물

HRID 1197420노트

반응식

HRID 1197420 반응식
[Cl:1][C:2]1[C:3]([C:7](Cl)=[O:8])=[CH:4][S:5][CH:6]=1.[NH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>O1CCOCC1.N1C=CC=CC=1>[Cl:1][C:2]1[C:3]([C:7]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:8])=[CH:4][S:5][CH:6]=1

참가 물질

5

반응물 2

HCID 6115AnilineHCID 129147964-Chlorothiophene-3-carbonyl chloride

생성물 1

HCID 15022346HCID 15022346, 화합물

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 312751,4-Dioxane용매

실험 절차

4-Chlorothiophene-3-carbonyl chloride (13.5 g, 0.075 mol) are dissolved in 30 ml of dioxane and the solution is added dropwise at room temperature to a solution of aniline (7.7 g, 0.083 mol) in pyridine (160 ml). Stirring is carried out for 12 hours at room temperature, after which the mixture is evaporated to dryness and the residue is taken up in dichloromethane. The organic phase is extracted with aqueous citric acid solution, sodium bicarbonate solution and water, dried and evaporated to dryness. Yield: 16.7 g, 94%; mp. 119° to 121° C.

후처리

  1. customafter which the mixture is evaporated to dryness
  2. extractionThe organic phase is extracted with aqueous citric acid solution, sodium bicarbonate solution and water
  3. customdried
  4. customevaporated to dryness

출처 및 근거

ORD 기록
ord-e533f948fa68494bbe427882048557a2
출처 데이터셋
uspto-grants-1994_01
특허 번호
US05276009

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