Pyridine → Gla-aht

HRID 1197423

반응식

[CH3:1][C:2]1[C:15](=[O:16])[N:14]=[C:13]2[N:4]([C@@H:5]3[O:9][C@H:8]([CH2:10][OH:11])[C@H:7]([O:12]2)[CH2:6]3)[CH:3]=1.N1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH3:18][CH2:19][CH2:20][CH2:21][CH2:22]/[CH:22]=[CH:21]\[CH2:20]/[CH:19]=[CH:18]\[CH2:22]/[CH:21]=[CH:20]\[CH2:19][CH2:18][CH2:6][CH2:7][C:8]([O:11][CH2:10][CH:8]1[O:9][CH:5]2[N:4]3[C:13]([O:12][CH:7]1[CH2:6]2)=[N:14][C:15](=[O:16])[C:2]([CH3:1])=[CH:3]3)=[O:9]

참가 물질

반응물 2

HCID 1049Pyridine2회

HCID 4579822,5-Methano-5H,9H-pyrimido(2,1-b)(1,5,3)dioxazepin-9-one, 2,3-dihydro-3-(hydroxymethyl)-8-methyl-, (2R,3R,5R)-

생성물 1

HCID 6475485Gla-aht

실험 절차

Anhydrothymidine (0.520 g, 2.319 mmol, as a dry white powder) was dissolved in anhydrous pyridine (10 ml) under an atmosphere of dry nitrogen, and to this stirred solution at room temperature was added GLA acid chloride (0.900 g, 3.02 mmol). Stirring was continued overnight after which period, TLC indicated complete loss of the starting material. The pyridine was

출처 및 근거

ORD 기록: ord-f4b0413425a043e68a1a6429d3d68dea
출처 데이터셋: uspto-grants-1994_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05276020

연결된 노트

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