HCID 14775259, 화합물 → HCID 178440008, 화합물

반응식

[NH:1]([C:3]1[C:8]([CH2:9][CH2:10][CH3:11])=[N:7][C:6]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)=[CH:5][N:4]=1)[NH2:2].[NH:18]1[CH:22]=[C:21]([CH2:23][CH:24]([C:30](OCC)=O)[C:25]([O:27][CH2:28][CH3:29])=[O:26])[N:20]=[CH:19]1>>[NH:18]1[CH:22]=[C:21]([CH2:23][CH:24]([C:30]2[N:4]3[CH:5]=[C:6]([C:12]4[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=4)[N:7]=[C:8]([CH2:9][CH2:10][CH3:11])[C:3]3=[N:1][N:2]=2)[C:25]([O:27][CH2:28][CH3:29])=[O:26])[N:20]=[CH:19]1

참가 물질

반응물 2

HCID 14775259HCID 14775259, 화합물

HCID 178471159HCID 178471159, 화합물

생성물 1

HCID 178440008HCID 178440008, 화합물

실험 절차

In a manner analogous to that described in Example 1, by condensing 2-hydrazino-3-propyl-5-(3-pyridyl)pyrazine with diethyl (imidazol-4-yl-methyl)malonate (J.Chem.Soc. 99, (1911) 1390) there is obtained ethyl rac-α-(imidazol-4-ylmethyl)-8-propyl-6-(3-pyridyl)-s-triazolo[4,3-a]pyrazine-3-acetate, MS: 405 (M)+, which is converted into the above acid by saponification analogously to Example 1.

출처 및 근거

ORD 기록: ord-967ffc8d1f74448d980e3a006ddceed5
출처 데이터셋: uspto-grants-1994_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05278161

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