참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Levodopa | HCID 6047 | — |
| 반응물 | L-Tyrosine | HCID 6057 | — |
| 반응물 | Dopachrome | HCID 119399 | — |
| 반응물 | Melanins | HCID 6325610 | — |
| 반응물 | Eumelanins | HCID 102582077 | — |
| 생성물 | 5,6-Dihydroxyindole | HCID 114683 | — |
반응 단계
As reported, for example, in Prota, Progress in the Chemist of Melanins and Related Metabolites, Med. Res. Reviews, 8:525-56 (1988), melanins are naturally occurring pigments present in hair and skin. In humans biosynthesis takes place in tyrosinase containing melanocytes. The tyrosinase enzyme catalyzes the hydroxylation of tyrosine to dopa and its subsequent oxidation to dopachrome. Once formed, dopachrome undergoes a series of complex reactions in the formation of eumelanins and phaeomelanins. Melanins provide black and deep brown pigments, and are formed by oxidative polymerization of 5,6-dihydroxyindole derived biogenetically during the melanogenesis. On the other hand, phaeomelanins provide yellow to reddish brown pigmentation to hair, and are formed by oxidative polymerization of cystein-S-yl-dopas via 1,4-benzothiazine intermediates.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05279618 |
|---|
| 출처 데이터셋 | uspto-grants-1994_01 |
|---|
| ORD ID | ord-14d7f07eea874e76bc9788326f81e766 |
|---|
| 출처 메모 | uspto-grants-1994_01 |
|---|
