N-Methylaniline → 2-Chloro-4-(N-methylphenylamino)thieno[2,3-d]pyrimidine

HRID 1198113노트

반응식

HRID 1198113 반응식
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[CH:10]=[CH:9][S:8][C:6]=2[N:7]=1.[CH3:12][NH:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(O)C>[Cl:1][C:2]1[N:3]=[C:4]([N:13]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH3:12])[C:5]2[CH:10]=[CH:9][S:8][C:6]=2[N:7]=1

참가 물질

4

반응물 2

HCID 7515N-MethylanilineHCID 122173242,4-Dichlorothieno[2,3-d]pyrimidine

생성물 1

HCID 103560572-Chloro-4-(N-methylphenylamino)thieno[2,3-d]pyrimidine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2,4-Dichlorothieno[2,3-d]pyrimidine (4.5 g, 0.022 mol) and N-methylaniline (4.7 g, 0.044 mol) in ethanol (50 ml) were stirred at room temperature for 72 hours. The solid obtained was collected by filtration, washed with ethanol and dried, 5.15 g. Recrystallization from ethyl acetate gave the title compound, m.p. 167°-168°.

후처리

  1. customThe solid obtained
  2. filtrationwas collected by filtration
  3. washwashed with ethanol
  4. customdried
  5. customRecrystallization from ethyl acetate

출처 및 근거

ORD 기록
ord-5033a70d127f425d83e1f8f3beeda801
출처 데이터셋
uspto-grants-1994_01
특허 번호
US05280026

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